Using Spatial Frequency Domain Imaging (SFDI) to quantify physiological changes of patients undergoing radiotherapy for breast cancer treatment
Paper 11211-4
Author(s): Adrien Ponticorvo, Rebecca A. Rowland, Oluwaseun Adelusi, Anaïs Leproux, Beckman Laser Institute and Medical Clinic (United States); Randy Wei, Memorial Radiation Oncology Medical Group (United States); Jeffrey Kuo, Parima Daroui, Nilam Ramsinghani, Muthana Al-Ghazi, Univ. of California, Irvine (United States); Anthony J. Durkin, Beckman Laser Institute and Medical Clinic (United States) 
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Radiotherapy is an effective treatment for certain breast cancers, but varying degrees of erythema can develop afterwards. Quantifying radiation-induced skin changes is challenging since there is no predictive tool to inform clinicians. Spatial Frequency Domain Imaging (SFDI), a non-contact quantitative imaging technique, was used to image breast cancer patients prescribed with radiation therapy. Preliminary analysis shows higher total hemoglobin concentration, and early changes in reduced scattering coefficient, compared to and untreated control. Further characterization of SFDI may assist clinicians with radiation protocols, thereby minimizing unnecessary skin toxicity while maximizing treatment efficacy.

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